Chromosome Organization
We are interested in the physical aspects of chromosome organization and dynamics that play a relevant physiological role in the cell. We model how bridging proteins, external tension and crowding from the nucleoplasm or the bacterial cytoplasm affect chromosome organization, dynamics and propagation of mechanical stress. We are particularly interested in the role played by chromosomes in cell cycle decisions.
Working on this topic: Marco Cosentino Lagomarsino, Mattia Corigliano
Key publications:
M Negri, M Gherardi, G Tiana and M Cosentino Lagomarsino, Spontaneous domain formation in disordered copolymers as a mechanism for chromosome structuring, Soft Matter, 14, 6128-6136 2018
KE Polovnikov, M Gherardi, M Cosentino Lagomarsino, MV Tamm, Folding and cytoplasm viscoelasticity contribute jointly to chromosome dynamics Physical Review Letters 120 (8), 088101, 2018
A Javer, NJ Kuwada, Z Long, VG Benza, KD Dorfman, PA Wiggins, P Cicuta, M Cosentino Lagomarsino, Persistent super-diffusive motion of Escherichia coli chromosomal loci. Nature Communications 5 3854, 2014