Evolution of Chromosomes
We work on evolutionary models that help us understand genome architecture. Our goal is to quantify the evolutionary forces that shape the structural variation of the genes and the genome, such as mutations and chromosome duplication, together with their effect on the reproductive fitness of the individuals. Recently, we have also set up a model that accounts for the aquisition and loss of DNA replication origins in Yeast.
Working on this topic: Simone Pompei, Rossana Droghetti
Key publications:
S Pompei, M Cosentino Lagomarsino, A fitness trade-off explains the early fate of yeast aneuploids with chromosome gains, Proceedings of the National Academy of Sciences 120 (15) 2023
R Droghetti, N Agier, G Fischer, M Gherardi, M Cosentino Lagomarsino, An evolutionary model identifies the main evolutionary biases for the evolution of genome-replication profiles. Elife 10, e63542 2021
M Yousuf, I Iuliani, RT Veetil, A Seshasayee, B Sclavi, M Cosentino Lagomarsino, Early fate of Exogenous promoters in E. coli, Nucleic acids research 48 (5), 2348-2356, 2020