Physiology of Cell Growth
We work on quantitative models for cell growth that describe how cells proliferate under different enviromental conditions. One of our main goals is understanding the regulatory circuits that govern cell growth and how those circuits react to perturbations such as nutrient limitations or drug treatment. We approach this question using both data-driven and model-driven methods: we make use of data provided from our experimental collaborators to build models, and we plan new experiments based on our models to test the model predictions. We are actively working on E. coli, yeast and cultured mammalian cell lines, to find common and specific traits of growth regulation.
Working on this topic: Rossana Droghetti, Mattia Corigliano, Giorgio Tallarico, Andrea Ripamonti
Key publications:
L Calabrese, L Ciandrini, M Cosentino Lagomarsino. How total mRNA influences cell growth. Proceedings of the National Academy of Sciences 121 (21) 2024
L Calabrese, J Grilli, M Osella, CP Kempes, M Cosentino Lagomarsino, L Ciandrini. Protein degradation sets the fraction of active ribosomes at vanishing growth. PLoS Comput Biol 18(5):e1010059 2022
Q Zhang, E Brambilla, R Li, H Shi, M Cosentino Lagomarsino, B Sclavi A decrease in transcription capacity limits growth rate upon translation inhibition. Msystems 5 (5) 2020